2310015K15Rik antibody, AA114818 antibody, Cager-2 antibody, D11Bwg0414e antibody, pur-beta antibody, purb antibody, zgc:65916 antibody, purb-b antibody, purbeta antibody, PURBETA antibody, si:dkey-202n14.1 antibody, purine rich element binding protein B antibody, purine-rich element binding protein Bb antibody, purine-rich element binding protein B L homeolog antibody, purine-rich element binding protein Ba antibody, Purb antibody, purbb antibody, purb.L antibody, PURB antibody, purba antibody
背景
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.Synonyms: Pur-beta, Purine-rich element-binding protein B, Transcriptional activator protein Pur-beta