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GSAP 抗体 (C-Term)

PION 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN954149
发货至: 中国
  • 抗原 See all GSAP (PION) 抗体
    GSAP (PION) (Pigeon Homolog (PION))
    抗原表位
    • 7
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 536-565, C-Term
    适用
    • 15
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    宿主
    • 15
    • 2
    • 1
    克隆类型
    • 17
    • 1
    多克隆
    标记
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    This GSAP antibody is un-conjugated
    应用范围
    • 18
    • 13
    • 10
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody recognizes Human PION (C-term).
    纯化方法
    Affinity Chromatography on Protein A
    免疫原
    KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PION
    亚型
    Ig Fraction
    Top Product
    Discover our top product PION Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    GSAP (PION) (Pigeon Homolog (PION))
    别名
    PION / GSAP (PION 产品)
    别名
    PION antibody, A530088I07Rik antibody, Pion antibody, gamma-secretase activating protein antibody, GSAP antibody, Gsap antibody
    背景
    Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog
    分子量
    97802 Da
    基因ID
    54103
    NCBI登录号
    NP_059135
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