The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.Synonyms: Paired basic amino acid cleaving enzyme 4, Proprotein convertase subtilisin/kexin type 6, SPC4, Subtilisin-like proprotein convertase 4, Subtilisin/kexin-like protease PACE4