NACC2 antibody, BTBD14A antibody, BEND9 antibody, BTBD14 antibody, BTBD31 antibody, Btbd14a antibody, 0610020I02Rik antibody, AI448087 antibody, C030048H19Rik antibody, NACC family member 2 antibody, nucleus accumbens-associated protein 2-like antibody, nucleus accumbens associated 2, BEN and BTB (POZ) domain containing antibody, NACC2 antibody, LOC100354269 antibody, Nacc2 antibody
背景
BTBD14A (BTB/POZ domain-containing protein 14A), also known as BTBD14, is a 587 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD14A may play a role in transcription regulation.Synonyms: BTB/POZ domain-containing protein 14A, Nucleus accumbens-associated protein 2