Mad3 antibody, BHLHC13 antibody, MAD3 antibody, MYX antibody, 4631412E13Rik antibody, bHLHc13 antibody, Mad antibody, zgc:66281 antibody, Myx antibody, MAX dimerization protein 3 antibody, Max dimerization protein 3 antibody, MAX dimerization protein 3 L homeolog antibody, mxd3 antibody, MXD3 antibody, Mxd3 antibody, mxd3.L antibody
背景
The MXD3 gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The Max-associated protein 3 / MAD3 forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.Synonyms: MAD-3, MXD3, Max-interacting transcriptional repressor MAD3