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HCAR2 抗体 (Middle Region)

HCAR2 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN952597
发货至: 中国
  • 抗原 See all HCAR2 抗体
    HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
    抗原表位
    • 8
    • 6
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    AA 207-236, Middle Region
    适用
    • 29
    • 11
    • 11
    • 1
    • 1
    • 1
    宿主
    • 28
    • 1
    克隆类型
    • 28
    • 1
    多克隆
    标记
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HCAR2 antibody is un-conjugated
    应用范围
    • 21
    • 16
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody recognizes Human GRP109A (Center). Other species not tested.
    纯化方法
    Protein A column, followed by peptide affinity purification
    免疫原
    KLH conjugated synthetic peptide between 207-236 amino acids from the Central region of human GPR109A Genename: NIACR1
    亚型
    Ig Fraction
    Top Product
    Discover our top product HCAR2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
    别名
    GPR109A (HCAR2 产品)
    别名
    GPR109A antibody, HCA2 antibody, HM74a antibody, HM74b antibody, NIACR1 antibody, PUMAG antibody, Puma-g antibody, Gpr109a antibody, Gpr109b antibody, HM74 antibody, Hcar2 antibody, PUMA-G antibody, Pumag antibody, mHM74b antibody, HCAR2 antibody, HCAR3 antibody, hydroxycarboxylic acid receptor 2 antibody, HCAR2 antibody, Hcar2 antibody, LOC527744 antibody
    背景
    NIACR1 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamideSynonyms: G-protein coupled receptor 109A, G-protein coupled receptor HM74A, HM74A, NIACR1, Niacin receptor 1, Nicotinic acid receptor, PUMA-G, Pumag
    分子量
    41850 Da
    基因ID
    338442
    NCBI登录号
    NP_808219
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