This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq].Synonyms: CEPR, CMKRL2, Chemoattractant receptor-like 2, DRY12, FEG1, Flow-induced endothelial G-protein coupled receptor 1, G-protein coupled estrogen receptor 1, G-protein coupled receptor 30, GPCR-BR, IL8-related receptor DRY12, LYGPR, Lymphocyte-derived G-protein coupled receptor