BHLHB8 antibody, MIST1 antibody, 1810009C13Rik antibody, Bhlhb8 antibody, MIST-1 antibody, Mist1 antibody, bHlH antibody, basic helix-loop-helix family member a15 antibody, basic helix-loop-helix family, member a15 antibody, BHLHA15 antibody, Bhlha15 antibody
背景
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).Synonyms: Class A basic helix-loop-helix protein 15, Class B basic helix-loop-helix protein 8, MIST1, Muscle, intestine and stomach expression 1