The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.Synonyms: ATL1, Brain-specific GTP-binding protein, GBP-3, GBP3, GTP-binding protein 3, Guanine nucleotide-binding protein 3, Spastic paraplegia 3 protein A