asxl1 antibody, MGC83850 antibody, mKIAA0978 antibody, BOPS antibody, MDS antibody, additional sex combs like 1, transcriptional regulator L homeolog antibody, additional sex combs like 1, transcriptional regulator antibody, additional sex combs like 1 antibody, asxl1.L antibody, ASXL1 antibody, asxl1 antibody, Asxl1 antibody
背景
This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.Synonyms: Additional sex combs-like protein 1, KIAA0978, Putative Polycomb group protein ASXL1