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HSD11B2 抗体 (Middle Region)

HSD11B2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN950176
发货至: 中国
  • 抗原 See all HSD11B2 抗体
    HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
    抗原表位
    • 16
    • 8
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 284-314, Middle Region
    适用
    • 44
    • 21
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 59
    • 4
    • 1
    克隆类型
    • 62
    • 2
    多克隆
    标记
    • 28
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HSD11B2 antibody is un-conjugated
    应用范围
    • 50
    • 24
    • 19
    • 14
    • 14
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应 (详细)
    Species reactivity (tested):Human
    纯化方法
    This antibody is purified through a protein A column; followed by peptide affinity purification.
    免疫原
    KLH conjugated synthetic peptide between 284~314 amino acids from the Central region of human HSD11B2.
    亚型
    Ig Fraction
    Top Product
    Discover our top product HSD11B2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
    别名
    11-beta HSD2 / HSD11B2 (HSD11B2 产品)
    别名
    MGC81883 antibody, 11-HSD2 antibody, AME antibody, AME1 antibody, HSD11K antibody, HSD2 antibody, SDR9C3 antibody, 11HSD2 antibody, HSD11B2 antibody, hydroxysteroid (11-beta) dehydrogenase 2 L homeolog antibody, hydroxysteroid 11-beta dehydrogenase 2 antibody, hsd11b2.L antibody, HSD11B2 antibody, Hsd11b2 antibody
    背景
    There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.Synonyms: 11-DH2, 11-beta-hydroxysteroid dehydrogenase 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, HSD11K, NAD-dependent 11-beta-hydroxysteroid dehydrogenase
    基因ID
    3291
    NCBI登录号
    NP_000187
    途径
    Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones
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