CDK1 抗体
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- 抗原 See all CDK1 抗体
- CDK1 (Cyclin-Dependent Kinase 1 (CDK1))
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适用
- 人, Cow, Non-Human Primate
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CDK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- 特异性
- The antibody POH-1 specifically detects Cdk1 (p34Cdc2, an intracellular antigen). Staining of Cdk1 reflects the proliferating potential of respective tissue.
- 无交叉反应
- Drosophila melanogaster, 小鼠, 大鼠, 非洲爪蟾
- 交叉反应 (详细)
- Human, Non-Human Primates, Bovine
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 免疫原
- Bacterially expressed full-length human Cdk1 protein
- 克隆位点
- POH-1
- 亚型
- IgG2a
- Top Product
- Discover our top product CDK1 Primary Antibody
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- 应用备注
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Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL, positive tissue: thymus.
Western blotting: Recommended dilution: 1-2 μg/mL. - 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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Distinct forms of human CDC2 identified by novel monoclonal antibodies." in: European journal of biochemistry / FEBS, Vol. 207, Issue 1, pp. 169-76, (1992) (PubMed).
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Distinct forms of human CDC2 identified by novel monoclonal antibodies." in: European journal of biochemistry / FEBS, Vol. 207, Issue 1, pp. 169-76, (1992) (PubMed).
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- 抗原
- CDK1 (Cyclin-Dependent Kinase 1 (CDK1))
- 别名
- Cdk1 (CDK1 产品)
- 背景
- Cyclin dependent kinase 1,Cdk1 (cyclin-dependent kinase 1), also known as p34Cdc2 (cell division control protein kinase 2) depends on cyclin A and B and is triggered by a positive feedback loop at the end of G2 phase, which is the key event that initiates mitotic entry. Destruction of cyclin B during metaphase results in inactivation of Cdk1, allowing mitotic exit and cell division. Cdk1 also contributes to the control of DNA replication. Cdk1 can be ihibited by several transcriptional targets of p53, such as p21WAF.,p34Cdc2, p34 protein kinase, CDK1, CDC2, CDC28A
- 基因ID
- 983
- UniProt
- B7Z3D6
- 途径
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA
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