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- 抗原 See all LAT2 抗体
- LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))
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抗原表位
- AA 196-212
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This LAT2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- The antibody NAP-03 recognizes a defined intracellular epitope (aa 196-212) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B cells, NK cells and myeloid cells.
- 无交叉反应
- 小鼠
- 交叉反应 (详细)
- Human
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 免疫原
- Peptide corresponding to aa 196-212 of human NTAL coupled to KLH.
- 克隆位点
- NAP-03
- 亚型
- IgG2a
- Top Product
- Discover our top product LAT2 Primary Antibody
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- 应用备注
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Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/mL, positive tissue: tonsil, germinal center.
Western blotting: Recommended dilution: 1-2 μg/mL, incubation 60 min, positive control: RAMOS human lymphoma cell line, non-reducing conditions, 12 % separating SDS-PAGE gel. - 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." in: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, (2002) (PubMed).
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Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." in: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, (2002) (PubMed).
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- 抗原
- LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))
- 别名
- NTAL / LAB (LAT2 产品)
- 别名
- LAB antibody, NTAL antibody, WBSCR15 antibody, WBSCR5 antibody, WSCR5 antibody, LAT2 antibody, MGC139435 antibody, Ntal antibody, Wbscr5 antibody, AW125574 antibody, Wbscr15 antibody, linker for activation of T-cells family member 2 antibody, linker for activation of T cells family, member 2 antibody, LAT2 antibody, Lat2 antibody
- 背景
- Linker for activation of T cells family member 2,NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.,LAB, LAT2
- 基因ID
- 7462
- UniProt
- Q9GZY6
- 途径
- Fc-epsilon Receptor Signaling Pathway, BCR Signaling
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