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CD80 抗体 (Extracellular Domain)

Name: CD80 抗体 (Extracellular Domain)
Brand: antibodies-online
SKU: ABIN94239
Availability: OutOfStock

CD80 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal MEM-233 unconjugated

Separation of CD80 transfected P815 cells stained using anti-human CD80 (MEM-233) purified antibody (concentration in sample 1. (CD80 抗体 (Extracellular Domain))

FACS

Surface staining of RAJI human Burkitt lymphoma cell line with anti-human CD80 (MEM-233) APC. (CD80 抗体 (Extracellular Domain))

FACS

2 images

(7 references)

产品编号 ABIN94239

发货至: 中国

Datasheet as PDF

抗原 See all CD80 抗体

CD80
抗原表位
16

15

11

10

8

6

6

4

4

4

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1
Extracellular Domain
适用
140

100

45

6

3

3

1

1

1
人
宿主
92

68

21

19

11

1

1
小鼠
Compatible Secondaries
克隆类型
128

82

2
单克隆
标记
85

19

17

17

12

5

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This CD80 antibody is un-conjugated
应用范围
124

92

67

34

31

20

14

13

13

12

11

10

8

4

2

2

2

1

1

1

1

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP)

特异性

The antibody MEM-233 reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.

交叉反应（详细）

Human

纯化方法

Purified by protein-A affinity chromatography.

纯度

> 95 % (by SDS-PAGE)

免疫原

Extracellular domain of human CD80 fused to human IgG1(Fc)

克隆位点

MEM-233

亚型

IgG1

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anti-CD80 (CD80) (AA 251-321) antibody
CD80 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-CD80 (CD80) (AA 38-246) antibody
CD80 适用: 小鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-CD80 (CD80) antibody
CD80 适用: 小鼠, 犬 FACS, IP, IHC (fro) 宿主: Armenian Hamster Monoclonal 16-10A1 unconjugated

anti-CD80 (CD80) (Extracellular Domain) antibody (FITC)
CD80 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-233 FITC

anti-CD80 (CD80) (Extracellular Domain) antibody (PE)
CD80 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-233 PE

anti-CD80 (CD80) (Extracellular Domain) antibody (APC)
CD80 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-233 APC

anti-CD80 (CD80) (Extracellular Domain) antibody (PerCP)
CD80 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-233 PerCP

anti-CD80 (CD80) antibody
CD80 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 2A2 unconjugated

anti-CD80 (CD80) (AA 111-265) antibody
CD80 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

Flow cytometry: Recommended dilution: 1-4 μg/mL.

限制

仅限研究用
浓度

1 mg/mL

缓冲液

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Do not freeze.

储存条件

4 °C

储存方法

Store at 2-8°C. Do not freeze.
Silk, Leishman, Nishimoto, Reddy, Fairchild: "Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype." in: Journal of biomedicine & biotechnology, Vol. 2012, pp. 172420, (2012) (PubMed).

Hovden, Karlsen, Jonsson, Aarstad, Appel: "Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses." in: BMC immunology, Vol. 12, pp. 2, (2011) (PubMed).

Lee, Sieling, Ochoa, Krutzik, Guo, Hernandez, Rea, Cheng, Colonna, Modlin: "LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 12, pp. 8128-36, (2007) (PubMed).

Kolar, Mehta, Pelayo, Capra: "A novel human B cell subpopulation representing the initial germinal center population to express AID." in: Blood, Vol. 109, Issue 6, pp. 2545-52, (2007) (PubMed).

Campioni, Moretti, Ferrari, Punturieri, Castoldi, Lanza: "Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: correlation with bone marrow microenvironment." in: Haematologica, Vol. 91, Issue 3, pp. 364-8, (2006) (PubMed).

Tan, Beutelspacher, Wang, McClure, Ritter, Lombardi, George: "Immunolipoplexes: an efficient, nonviral alternative for transfection of human dendritic cells with potential for clinical vaccination." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 11, Issue 5, pp. 790-800, (2005) (PubMed).

Zhan, Towler, Calder: "The immunomodulatory role of human conjunctival epithelial cells." in: Investigative ophthalmology & visual science, Vol. 44, Issue 9, pp. 3906-10, (2003) (PubMed).
抗原

CD80

别名

CD80 (CD80 产品)

别名

B7 antibody, B7-1 antibody, B7.1 antibody, BB1 antibody, CD28LG antibody, CD28LG1 antibody, LAB7 antibody, B71 antibody, Cd28l antibody, Ly-53 antibody, Ly53 antibody, MIC17 antibody, TSA1 antibody, CD80 molecule antibody, Cd80 molecule antibody, CD80 antigen antibody, CD80 antibody, Cd80 antibody

背景

CD80 Molecule,CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 Molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet, there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.,B7-1, BB1

基因ID

941

UniProt

P33681

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints