Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) 抗体
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- 抗原 See all Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) 抗体
- Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB), Dot Blot (DB)
- 交叉反应
- 人, 小鼠
- 交叉反应 （详细）
- Other species not studied.
- 纯化方法
- Protein G affinity chromatography
- 免疫原
- CBLB antibody was raised in mouse using recombinant Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B
- 克隆位点
- 246C5a
- 亚型
- IgG2a
- Top Product
- Discover our top product CBLB Primary Antibody
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anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 101-200) antibody
CBLB 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (N-Term) antibodyCBLB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 1-350) antibodyCBLB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 103-130) antibodyCBLB 适用: 大鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21574 unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) antibodyCBLB 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (C-Term) antibodyCBLB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: 0.2-2 µg/mL
Optimal conditions should be determined by the investigator. - 限制
- 仅限研究用
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- 浓度
- Lot specific
- 缓冲液
- CBLB antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. - 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.
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- 抗原
- Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)
- 别名
- CBLB (CBLB 产品)
- 别名
- rnf56 antibody, cblb antibody, AI429560 antibody, AI851073 antibody, Cbl-b antibody, Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog antibody, Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog antibody, Casitas B-lineage lymphoma b antibody, Cbl proto-oncogene B antibody, cblb.S antibody, cblb.L antibody, Cblb antibody, CBLB antibody
- 背景
- E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. Synonyms: Monoclonal CBLB antibody, Anti-CBLB antibody, Cas-Br-M (murine) ecotropic retroviral transforming sequence b antibody, RNF56 antibody, Nbla00127 antibody.
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