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AP2A2 抗体 (C-Term)

AP2A2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN929411
发货至: 中国
  • 抗原 See all AP2A2 抗体
    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
    抗原表位
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    C-Term
    适用
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    宿主
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    克隆类型
    • 39
    多克隆
    标记
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    This AP2A2 antibody is un-conjugated
    应用范围
    • 32
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    Western Blotting (WB)
    纯化方法
    Purified
    免疫原
    AP2 A2 antibody was raised in rabbit using the C terminal of AP2 2 as the immunogen
    Top Product
    Discover our top product AP2A2 Primary Antibody
  • 应用备注
    WB: 0.2-1 µg/mL
    Optimal conditions should be determined by the investigator.
    说明

    AP2A2 Blocking Peptide, catalog no. 33R-8256, is also available for use as a blocking control in assays to test for specificity of this AP2A2 antibody

    限制
    仅限研究用
  • 状态
    Lyophilized
    浓度
    Lot specific
    缓冲液
    Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
    注意事项
    Avoid repeated freeze/thaw cycles.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
  • 抗原
    AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
    别名
    AP2A2 (AP2A2 产品)
    别名
    MGC99219 antibody, ADTAB antibody, CLAPA2 antibody, HIP-9 antibody, HIP9 antibody, HYPJ antibody, 2410074K14Rik antibody, AF006990 antibody, AW146353 antibody, Adtab antibody, C78001 antibody, L25 antibody, adaptor related protein complex 2 alpha 2 subunit antibody, adaptor related protein complex 2 alpha 2 subunit L homeolog antibody, adaptor-related protein complex 2, alpha 2 subunit antibody, AP2A2 antibody, ap2a2.L antibody, Ap2a2 antibody
    背景
    AP2A2 is a component of the adaptor protein complex 2 (AP-2). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. Synonyms: Polyclonal AP2A2 antibody, Anti-AP2A2 antibody, adaptor-related protein complex 2, alpha 2 subunit antibody, ADTAB antibody, CLAPA2 antibody, HIP9 antibody, HYPJ antibody.
    途径
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome
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