UBA3 抗体 (N-Term)
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- 抗原 See all UBA3 抗体
- UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠, 斑马鱼, Cow, 犬, 小鸡, 非洲爪蟾
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This UBA3 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 小鼠, 大鼠, 牛, 犬, 小鸡, Frog, 斑马鱼
- 纯化方法
- Purified
- 免疫原
- UBA3 antibody was raised in rabbit using the N terminal of UBA3 as the immunogen
- Top Product
- Discover our top product UBA3 Primary Antibody
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- 应用备注
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WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator. - 说明
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UBA3 Blocking Peptide, catalog no. 33R-2446, is also available for use as a blocking control in assays to test for specificity of this UBA3 antibody
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
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- 抗原
- UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
- 别名
- UBA3 (UBA3 产品)
- 别名
- UBE1C antibody, hUBA3 antibody, Ube1c antibody, ube1c antibody, wu:fb75e04 antibody, wu:fc37b11 antibody, zgc:55528 antibody, A830034N06Rik antibody, AI256736 antibody, AI848246 antibody, AW546539 antibody, ubiquitin like modifier activating enzyme 3 antibody, ubiquitin-like modifier activating enzyme 3 antibody, ubiquitin like modifier activating enzyme 3 S homeolog antibody, UBA3 antibody, Uba3 antibody, uba3 antibody, uba3.S antibody
- 背景
- UBA3 is a catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. UBA3 down-regulates steroid receptor activity. UBA3 is necessary for cell cycle progression.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. Synonyms: Polyclonal UBA3 antibody, Anti-UBA3 antibody, ubiquitin-like modifier activating enzyme 3 antibody, DKFZp566J164 antibody, MGC22384 antibody, UBE1C antibody, hUBA3 antibody.
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