ZW10 抗体 (AbBy Fluor® 350)
-
- 抗原 See all ZW10 抗体
- ZW10 (Zw10 Kinetochore Protein (ZW10))
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This ZW10 antibody is conjugated to AbBy Fluor® 350
-
应用范围
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 预测反应
- Human,Mouse,Rat
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from mouse ZW10
- 亚型
- IgG
- Top Product
- Discover our top product ZW10 Primary Antibody
-
anti-Zw10 Kinetochore Protein (ZW10) (AA 1-100) antibody
ZW10 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2E5 unconjugated
anti-Zw10 Kinetochore Protein (ZW10) antibodyZW10 适用: 人 WB, ICC, IP, DB 宿主: 小鼠 Monoclonal 3363C4a unconjugated
anti-Zw10 Kinetochore Protein (ZW10) (AA 71-120) antibodyZW10 适用: 人, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Zw10 Kinetochore Protein (ZW10) (AA 1-779) antibodyZW10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Zw10 Kinetochore Protein (ZW10) (N-Term) antibodyZW10 适用: 人, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- IF(IHC-P) 1:50-200
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
-
- 抗原
- ZW10 (Zw10 Kinetochore Protein (ZW10))
- Abstract
- ZW10 产品
- 别名
- HZW10 antibody, KNTC1AP antibody, 6330566F14Rik antibody, MmZw10 antibody, zw10 kinetochore protein antibody, ZW10 antibody, Zw10 antibody
- 背景
-
Synonyms: Centromere/kinetochore protein zw10, Centromere/kinetochore protein zw10 homolog, HZW 10, HZW10, Kinetochore associated homolog, KNTC1AP, MGC149821, Zeste White 10, Zeste white 10 homolog, ZW 10, ZW 10, centromere/kinetochore protein, ZW 10 kinetochore associated homolog, ZW10 Drosophila homolog centromere/kinetochore protein, ZW10 homolog centromere/kinetochore protein Drosophila, ZW10 homolog centromere/kinetochore protein, ZW10 kinetochore associated homolog, ZW10_MOUSE.
Background: The mitotic checkpoint ensures that chromosomes are divided equally between daughter cells and is a primary mechanism preventing the chromosome instability often seen in aneuploid human tumors. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase. It is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. In mitotic human cells ZW10 resides in a complex with Rod and Zwilch, whereas another ZW10 partner, Zwint-1, is part of a separate complex of structural kinetochore components including Mis12 and Ndc80-Hec1. Zwint-1 is critical for recruiting ZW10 to unattached kinetochores. Depletion from human cells demonstrates that the ZW10 complex is essential for stable binding of a Mad1-Mad2 complex to unattached kinetochores. Thus, ZW10 functions as a linker between the core structural elements of the outer kinetochore and components that catalyze generation of the mitotic checkpoint-derived "stop anaphase" inhibitor.
- 基因ID
- 9183
-
