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HBxAg 抗体 (AbBy Fluor® 350)

HBxAg 适用: Hepatitis B Virus (HBV) WB, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 350
产品编号 ABIN920136
发货至: 中国
  • 抗原 See all HBxAg products
    HBxAg (Hepatitis B Virus X Antigen (HBxAg))
    适用
    • 21
    • 7
    • 7
    • 7
    • 4
    Hepatitis B Virus (HBV)
    宿主
    • 16
    • 16
    克隆类型
    • 16
    • 16
    多克隆
    标记
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This HBxAg antibody is conjugated to AbBy Fluor® 350
    应用范围
    • 23
    • 12
    • 12
    • 11
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    Virus
    交叉反应 (详细)
    Hepatitis B virus
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from Hepatitis B virus X protein
    亚型
    IgG
  • 应用备注
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    HBxAg (Hepatitis B Virus X Antigen (HBxAg))
    别名
    Hepatitis B Virus X Protein (HBxAg 产品)
    物质类
    Viral Protein
    背景

    Synonyms: HBX, pre-X protein, HB-X, X protein, HBV X protein, X protein [Hepatitis B virus].

    Background: Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1 (By similarity).

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