RPS3 抗体 (AA 101-200) (AbBy Fluor® 488)
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- 抗原 See all RPS3 抗体
- RPS3 (Ribosomal Protein S3 (RPS3))
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抗原表位
- AA 101-200
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适用
- 人, 小鼠, 非洲爪蟾
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RPS3 antibody is conjugated to AbBy Fluor® 488
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人, 小鼠, 非洲爪蟾
- 预测反应
- Rat,Zebrafish
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human RPS3
- 亚型
- IgG
- Top Product
- Discover our top product RPS3 Primary Antibody
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- RPS3 (Ribosomal Protein S3 (RPS3))
- 别名
- RPS3 (RPS3 产品)
- 别名
- S3 antibody, D7Ertd795e antibody, Rs_3 antibody, fb13d09 antibody, wu:fb13d09 antibody, zgc:56088 antibody, ribosomal protein S1a antibody, rps3 antibody, 6779 antibody, CG6779 antibody, DmRpS3 antibody, Dmel\\CG6779 antibody, M(3)124 antibody, M(3)95A antibody, M(3)B antibody, M(3)B2 antibody, M(3)Fla antibody, M(3)w antibody, M(3R)w antibody, M95A antibody, M[[w]] antibody, Mw antibody, RPS3 antibody, RS3 antibody, Rp S3 antibody, RpS antibody, Rps3 antibody, X72921 antibody, dS3 antibody, rpS3 antibody, rpls1b antibody, rpls3-b antibody, ribosomal protein S3 antibody, 40S ribosomal protein S3 antibody, ribosomal protein S3 L homeolog antibody, Ribosomal protein S3 antibody, 30S ribosomal protein S3 antibody, ribosomal protein S3 S homeolog antibody, RPS3 antibody, Rps3 antibody, rps-3 antibody, rps3 antibody, rps3.L antibody, RpS3 antibody, rps3.S antibody
- 背景
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Synonyms: S3, 40S ribosomal protein S3, RPS3, OK/SW-cl.26
Background: Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).
- 基因ID
- 6188
- UniProt
- P23396
- 途径
- Positive Regulation of Endopeptidase Activity
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