PIDD 抗体 (AA 551-650) (AbBy Fluor® 647)
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- 抗原 See all PIDD 抗体
- PIDD (P53-Induced Death Domain Protein (PIDD))
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抗原表位
- AA 551-650
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIDD antibody is conjugated to AbBy Fluor® 647
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应用范围
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 大鼠
- 预测反应
- Human,Mouse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human LRDD/PIDD
- 亚型
- IgG
- Top Product
- Discover our top product PIDD Primary Antibody
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anti-P53-Induced Death Domain Protein (PIDD) (AA 1-85) antibody
PIDD 适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) antibodyPIDD 适用: 人, 大鼠, 小鼠 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 776-910) antibodyPIDD 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3C5G8 unconjugated
anti-P53-Induced Death Domain Protein (PIDD) antibodyPIDD 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 776-910) antibodyPIDD 适用: 人, 小鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal Anto-1 unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 467-516) antibodyPIDD 适用: 人, 豚鼠, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 143-192) antibodyPIDD 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 668-917) antibodyPIDD 适用: 大鼠 IHC, WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (Middle Region) antibodyPIDD 适用: 人, 大鼠, 小鼠, 豚鼠, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- PIDD (P53-Induced Death Domain Protein (PIDD))
- 别名
- LRDD (PIDD 产品)
- 别名
- 1200011D09Rik antibody, AU042446 antibody, Pidd antibody, LRDD antibody, Lrdd antibody, p53 induced death domain protein 1 antibody, p53-induced death domain protein 1 antibody, Pidd1 antibody, PIDD1 antibody
- 背景
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Synonyms: Leucine rich repeats and death domain containing, Leucine-rich repeats and death domain containing, MGC16925, p53-induced protein with a death domain, PIDD, DKFZp434D229, PIDD_HUMAN.
Background: The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression. Independently, PIDD was also described as a DD-containing protein with unknown function. The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, followed by two ZU-5 domains and a C-terminal DD. PIDD forms a complex with caspase-2 and the adaptor protein RAIDD. Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, via interaction with caspase-2 and CRADD/RAIDD. PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, an important component for activation of the transcription factor NF-kappa-B.
- 途径
- p53 Pathway, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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