Lipin 1 抗体 (AA 501-600) (Biotin)
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- 抗原 See all Lipin 1 (LPIN1) 抗体
- Lipin 1 (LPIN1)
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抗原表位
- AA 501-600
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Lipin 1 antibody is conjugated to Biotin
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应用范围
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 大鼠
- 预测反应
- Human,Mouse,Dog,Cow,Sheep,Pig,Rabbit,Chimpanzee,Goose
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Lipin 1
- 亚型
- IgG
- Top Product
- Discover our top product LPIN1 Primary Antibody
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- 应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- Lipin 1 (LPIN1)
- 别名
- Lipin 1 (LPIN1 产品)
- 别名
- LPIN1 antibody, pap1 antibody, PAP1 antibody, 4631420P06 antibody, Kiaa0188 antibody, Lipin1 antibody, fld antibody, mKIAA0188 antibody, zgc:194552 antibody, zgc:194558 antibody, lipin1 antibody, lipin 1 antibody, phosphatidate phosphatase LPIN1 antibody, LPIN1 antibody, lpin1 antibody, LOC100539289 antibody, Lpin1 antibody
- 背景
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Synonyms: KIAA0188, LPIN1, PAP1, Phosphatidate phosphatase LPIN1, LPIN1_HUMAN.
Background: Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
- 基因ID
- 23175
- 途径
- Monocarboxylic Acid Catabolic Process
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