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Deltex Homolog 1 抗体 (AA 351-450) (AbBy Fluor® 488)

DTX1 适用: 人, 小鼠, 大鼠 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 488
产品编号 ABIN893885
发货至: 中国
  • 抗原 See all Deltex Homolog 1 (DTX1) 抗体
    Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))
    抗原表位
    • 15
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 351-450
    适用
    • 42
    • 24
    • 16
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 42
    • 1
    克隆类型
    • 43
    多克隆
    标记
    • 15
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Deltex Homolog 1 antibody is conjugated to AbBy Fluor® 488
    应用范围
    • 31
    • 14
    • 13
    • 13
    • 9
    • 8
    • 7
    • 5
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    人, 小鼠, 大鼠
    预测反应
    Cow
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Deltex-1
    亚型
    IgG
    Top Product
    Discover our top product DTX1 Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))
    别名
    Deltex 1 (DTX1 产品)
    别名
    hDx-1 antibody, Fxit1 antibody, mKIAA4160 antibody, deltex antibody, dtx antibody, xdtx1 antibody, deltex E3 ubiquitin ligase 1 antibody, deltex homolog 1 (Drosophila) antibody, deltex 1, E3 ubiquitin ligase antibody, deltex 1 L homeolog antibody, deltex 1 S homeolog antibody, DTX1 antibody, dtx1 antibody, Dtx1 antibody, dtx1.L antibody, dtx1.S antibody
    背景

    Synonyms: hDx-1, E3 ubiquitin-protein ligase DTX1, Protein deltex-1, Deltex1, hDTX1, DTX1

    Background: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

    基因ID
    1840
    UniProt
    Q86Y01
    途径
    Notch Signaling
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