INPP5D 抗体 (pTyr1020) (AbBy Fluor® 350)
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- 抗原 See all INPP5D 抗体
- INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
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抗原表位
- pTyr1020
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适用
- 人, 小鼠, 猴
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This INPP5D antibody is conjugated to AbBy Fluor® 350
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS)
- 交叉反应
- 人, 猴, 小鼠
- 预测反应
- Rat,Dog,Cow,Pig
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human SHIP1 around the phosphorylation site of Tyr1020
- 亚型
- IgG
- Top Product
- Discover our top product INPP5D Primary Antibody
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- 应用备注
- FCM 1:20-100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
- 别名
- SHIP1 (INPP5D 产品)
- 别名
- INPP5D antibody, 256.t00004 antibody, 13.t00027 antibody, ship antibody, ship1 antibody, AI323613 antibody, SHIP antibody, SHIP-1 antibody, SHIP1 antibody, s-SHIP antibody, SIP-145 antibody, hp51CN antibody, inositol polyphosphate-5-phosphatase D antibody, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 antibody, inositol polyphosphate 5-phosphatase antibody, inositol polyphosphate-5-phosphatase D L homeolog antibody, INPP5D antibody, LOC100446045 antibody, inpp5d antibody, EHI_159880 antibody, EHI_153490 antibody, inpp5d.L antibody, LOC100380693 antibody, Inpp5d antibody
- 背景
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Synonyms: P-SHIP1 Tyr1020, Inositol polyphosphate 5 phosphatase of 145 kDa, 4, 5-trisphosphate 5-phosphatase 1, hp51CN, hSHIP, Inositol polyphosphate 5 phosphatase 145 kDa, Inositol polyphosphate 5 phosphatase, Inositol polyphosphate 5 phosphatase D, Inositol polyphosphate-5-phosphatase of 145 kDa, INPP 5D, INPP5D, INPP5D protein, MGC104855, MGC142140, MGC142142, p150 ship, p150Ship, Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1, Phosphatidylinositol-3, SH2 containing inositol 5 phosphatase, SH2 containing inositol phosphatase isoform b, SH2 domain containing inositol 5' phosphatase 1, SH2 domain containing inositol phosphatase 1, SH2 domain-containing inositol phosphatase 1, SH2 domain-containing inositol-5''-phosphatase 1, SHIP 1, SHIP-1, SHIP1, SHIP1_RAT, Signaling inositol polyphosphate 5 phosphatase SIP 145, Signaling inositol polyphosphate 5 phosphatase SIP145, SIP 145, SIP-145, SIP145.
Background: SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.
- 基因ID
- 3635
- 途径
- TCR Signaling, BCR Signaling, Warburg Effect
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