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Complement C3c 抗体 (AA 1051-1200)

C3C 适用: 人, 大鼠, Pig ELISA, WB, ICC, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN873279
发货至: 中国
  • 抗原 See all Complement C3c (C3C) products
    Complement C3c (C3C) (Complement Component C3c (C3C))
    抗原表位
    • 14
    • 3
    • 2
    AA 1051-1200
    适用
    • 60
    • 27
    • 16
    • 15
    • 14
    • 12
    • 5
    • 4
    • 3
    • 1
    人, 大鼠, Pig
    宿主
    • 71
    • 26
    • 10
    • 9
    • 2
    • 2
    克隆类型
    • 114
    • 4
    多克隆
    标记
    • 36
    • 34
    • 16
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Complement C3c antibody is un-conjugated
    应用范围
    • 70
    • 51
    • 32
    • 30
    • 26
    • 19
    • 13
    • 13
    • 12
    • 12
    • 11
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    人, Pig, 大鼠
    预测反应
    Mouse,Dog
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Complement C3c alpha' chain fragment 1
    亚型
    IgG
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • Vass, Süveges, Érces, Nógrády, Varga, Földesi, Futakuchi, Imai, Okada, Okada, Boros, Kaszaki: "Inflammatory activation after experimental cardiac tamponade." in: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes, Vol. 51, Issue 1-2, pp. 1-13, (2013) (PubMed).

  • 抗原
    Complement C3c (C3C) (Complement Component C3c (C3C))
    别名
    Complement Fragment 3c (C3C 产品)
    背景

    Synonyms: ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3

    Background: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:837664, PubMed:29953, PubMed:959512, PubMed:1432298, PubMed:15833747, PubMed:16333141, PubMed:1961575).

    基因ID
    718
    UniProt
    P01024
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