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ARRDC3 抗体 (AA 178-215)

ARRDC3 适用: 小鼠 ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN872868
发货至: 中国
  • 抗原 See all ARRDC3 products
    ARRDC3 (Arrestin Domain Containing 3 (ARRDC3))
    抗原表位
    • 6
    • 6
    • 2
    • 1
    • 1
    AA 178-215
    适用
    • 23
    • 14
    • 14
    • 1
    小鼠
    宿主
    • 24
    克隆类型
    • 24
    多克隆
    标记
    • 13
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ARRDC3 antibody is un-conjugated
    应用范围
    • 13
    • 12
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    小鼠
    预测反应
    Human,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human ARRDC3 corresponding to amino acids 178-215.
    亚型
    IgG
  • 应用备注
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    ARRDC3 (Arrestin Domain Containing 3 (ARRDC3))
    别名
    ARRDC3 (ARRDC3 产品)
    别名
    TLIMP antibody, AI450344 antibody, mKIAA1376 antibody, LRRGT00048 antibody, ARRDC3 antibody, arrdc3 antibody, si:dkey-172m14.3 antibody, wu:fc21e01 antibody, zgc:136956 antibody, MGC131006 antibody, DKFZp469D0714 antibody, zgc:92034 antibody, arrestin domain containing 3 antibody, arrestin domain containing 3a antibody, arrestin domain containing 3 S homeolog antibody, arrestin domain containing 3b antibody, ARRDC3 antibody, Arrdc3 antibody, arrdc3 antibody, arrdc3a antibody, arrdc3.S antibody, arrdc3b antibody
    背景

    Synonyms: ARRDC 3, Arrestin domain containing protein 3, KIAA1376, Thioredoxin binding protein 2 like inducible membrane, TLIMP, ARRD3_HUMAN.

    Background: The arrestins are a family of proteins that are important for regulating signal transduction within cells. Arrestins are part of a conserved two step mechanism for regulating the activity of G-protein coupled receptors (GPCRs). In response to a stimulus, GPCRs activate a heterotrimeric G protein. In order to turn off this response, or adapt to a constant stimulus, activated receptors need to be silenced. The first step is phosphorylation by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs). This phosphorylation specifically marks the activated receptor for arrestin binding. Once arrestin is bound to the receptor it is unable to signal further. Recent research continues to expand the known actions of arrestins, which can bind to other classes of receptors and can directly activate signaling pathways on their own. Different arrestins (visual arrestin (or Arrestin 1), beta-arrestin 1 (or Arrestin 2) and beta-arrestin 2 (or Arrestin 3) can reduce the activity of their target GPCRs in several different ways.

    基因ID
    57561
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