The antibody detects endogenous level of total Adiponectin protein.
纯化方法
Affinity purified
免疫原
Peptide sequence around AA 235-239 (T-G-F-L-L) derived from Human Adiponectin. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-a by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex,