The antibody detects endogenous level of total SPARC protein.
纯化方法
Affinity purified
免疫原
Peptide sequence around AA 52-56 (V-G-E-F-D) derived from Human SPARC. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites, an acidic domain that binds 5 to 8 Ca2+ with a low affinity and an EF-hand loop that binds a Ca2+ ion with a high affinity.