p53 抗体
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- 抗原 See all p53 (TP53) 抗体
- p53 (TP53) (Tumor Protein P53 (TP53))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This p53 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of N-terminal residues of p53.
- 交叉反应
- 人, 小鼠
- 产品特性
- Positive Control: A431. Cellular Localization: Cytoplasm, nucleus
- 纯化方法
- Immunogen affinity purified
- 亚型
- IgG
- Top Product
- Discover our top product TP53 Primary Antibody
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- 应用备注
- WB: 1:500-1,000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5mg/ml
- 缓冲液
- 1xTBS (pH7.4), 0.5% BSA, 25% Glycerol
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
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- 抗原
- p53 (TP53) (Tumor Protein P53 (TP53))
- 别名
- p53 (TP53 产品)
- 背景
- P53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. It acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. P53 is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. p53 is frequently mutated or inactivated in about 60% of cancers
- 分子量
- ~70kDa
- UniProt
- Q91XH8
- 途径
- p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
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