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MDM2 抗体 (pSer186)

Name: MDM2 抗体 (pSer186)
SKU: ABIN802548
Availability: OutOfStock

MDM2 适用: 人 WB, ELISA, IHC (p), IF (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded human gastric cancer labeled with Anti-Phospho-MDM2(Ser186) Polyclonal Antibody, Unconjugated (ABIN802548) at 1:200 followed by conjugation to the secondary antibody and DAB staining (MDM2 抗体 (pSer186))

IHC

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-MDM2(Ser186) Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining (MDM2 抗体 (pSer186))

IHC (p)

ELISA

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-Phospho-MDM2(Ser186) Polyclonal Antibody, Unconjugated (ABIN802548) at 1:200 followed by conjugation to the secondary antibody and DAB staining (MDM2 抗体 (pSer186))

IHC

4 images

产品编号 ABIN802548

发货至: 中国

Datasheet as PDF

抗原 See all MDM2 抗体

MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
抗原表位
25

24

15

10

10

10

10

9

8

8

7

4

4

4

3

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer186
适用
191

75

49

12

2

1

1

1

1

1
人
宿主
168

26

1
兔
Compatible Secondaries
克隆类型
169

26
多克隆
标记
97

13

9

9

7

6

4

4

4

4

4

4

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1
This MDM2 antibody is un-conjugated
应用范围
125

77

63

38

26

26

26

18

18

14

11

8

5

4

3

2

2

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人

预测反应

Dog,Cow,Pig,Horse,Chicken,Rabbit,Guinea Pig

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human MDM2 around the phosphorylation site of Ser186

亚型

IgG

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anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 101-200) antibody
MDM2 适用: 人 WB, ELISA, IHC (p), RNAi, PLA 宿主: 小鼠 Monoclonal 1A7 unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 130-230) antibody
MDM2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (Center) antibody
MDM2 适用: 人, 小鼠 WB, IF, IHC (p), IP, ICC, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (pSer166) antibody
MDM2 适用: 人, 小鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 26-169) antibody
MDM2 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 3C1E3 unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 393-424) antibody
MDM2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) antibody
MDM2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 119-438) antibody
MDM2 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1E6 unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 200-430) antibody
MDM2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 26-169) antibody
MDM2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4A8D12 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

别名

MDM2 (MDM2 产品)

别名

ACTFS antibody, HDMX antibody, hdm2 antibody, zgc:109834 antibody, 1700007J15Rik antibody, AA415488 antibody, Mdm-2 antibody, MDM2 proto-oncogene antibody, MDM2 proto-oncogene S homeolog antibody, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) antibody, MDM2 oncogene, E3 ubiquitin protein ligase antibody, transformed mouse 3T3 cell double minute 2 antibody, MDM2 antibody, mdm2.S antibody, Mdm2 antibody, mdm2 antibody

背景

Synonyms: HDMX, hdm2, ACTFS, E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein, Oncoprotein Mdm2, p53-binding protein Mdm2, MDM2
Background: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.

基因ID

4193

UniProt

Q00987

途径

p53 Pathway, PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Autophagy, Ubiquitin Proteasome Pathway