ISR-beta 抗体 (pTyr1185)
(1 reference)-
- 抗原 See all ISR-beta 抗体
- ISR-beta (Insulin Receptor beta (ISR-beta))
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抗原表位
- pTyr1185
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ISR-beta antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Dog,Cow,Pig,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human INSR around the phosphorylation site of Tyr1185 [DI(p-Y)ET]
- 亚型
- IgG
- Top Product
- Discover our top product ISR-beta Primary Antibody
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anti-Insulin Receptor beta (ISR-beta) (AA 801-900) antibody
ISR-beta 适用: 人, 大鼠, 小鼠 FACS, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor beta (ISR-beta) (AA 1001-1100) antibodyISR-beta 适用: 人, 大鼠 WB, FACS, IF (cc), IF (p), ELISA, IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor beta (ISR-beta) (pTyr1355) antibodyISR-beta 适用: 人, 大鼠, 小鼠 WB, FACS, IF (cc), IF (p), ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor beta (ISR-beta) (Cytoplasmic Domain) antibodyISR-beta 适用: 人, 大鼠, 小鼠, Cow, Pig, Hamster, 兔, 绵羊 WB 宿主: 小鼠 Monoclonal C18C4 unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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: "Stearic acid serves as a potent inhibitor of protein tyrosine phosphatase 1B." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 32, Issue 5, pp. 1451-9, (2014) (PubMed).
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: "Stearic acid serves as a potent inhibitor of protein tyrosine phosphatase 1B." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 32, Issue 5, pp. 1451-9, (2014) (PubMed).
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- 抗原
- ISR-beta (Insulin Receptor beta (ISR-beta))
- 别名
- Insulin Receptor Beta (ISR-beta 产品)
- 别名
- CD220 antibody, HHF5 antibody, 4932439J01Rik antibody, D630014A15Rik antibody, IR antibody, IR-A antibody, IR-B antibody, insulin receptor antibody, INSR antibody, Insr antibody
- 背景
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Synonyms: HHF5, CD22, Insulin receptor, IR, INSR
Background: The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
- 基因ID
- 3643
- UniProt
- P06213
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