This antibody is expected to recognize isoform a (NP_008830.2) and isoform b (NP_777280.1).
交叉反应 (详细)
Species reactivity (expected):Canine (Dog), Pig. Species reactivity (tested):Human, Mouse, Rat.
纯化方法
Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
免疫原
Synthetic peptide with a Cysteine residue linker, corresponding to internal sequence amino acids 33-46 of Human IDH3B (NP_008830.2, NP_777280.1) Genename: IDH3B
Defects in IDH3B are the cause of retinitis pigmentosa type 46 (RP46) [MIM:612572]. RP is a retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the isocitrate and isopropylmalate dehydrogenases family.Synonyms: NAD(+)-specific ICDH beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta