ITI-HC4 antibody, Itih-4 antibody, GP120 antibody, H4P antibody, IHRP antibody, ITIHL1 antibody, PK-120 antibody, PK120 antibody, inter alpha-trypsin inhibitor, heavy chain 4 antibody, inter-alpha-trypsin inhibitor heavy chain family member 4 antibody, inter-alpha-trypsin inhibitor heavy chain family, member 4 antibody, Itih4 antibody, ITIH4 antibody
背景
The inter-a-trypsin inhibitor (ITI, IaI) family, a typical and classical example for protein-glycosaminoglycanprotein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family, it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.Synonyms: Gp120, IHRP, ITI heavy chain H4, ITI-HC4, ITIHL1, Inter-alpha-inhibitor heavy chain 4, Inter-alpha-trypsin inhibitor family heavy chain-related protein, Inter-alpha-trypsin inhibitor heavy chain H4, PK120, Plasma kallikrein sensitive glycoprotein 120