The Storkhead box protein 2 (STOX2) is the only known paralog to STOX1, a winged-helix domain containing transcription factor believed to play a role in the differentiation of stem cells. STOX2 has been suggested to be part of a molecular profile unique to stem cells, and its mRNA may be part of a transcriptional profile observed with increased inflammatory response to air pollutants. Decreased STOX2 expression levels in decidua are also correlated with preeclampsia, suggesting STOX2 may play a role in the pathophysiology of preeclampsia.