2600017H02Rik antibody, RGD1561781 antibody, zgc:77242 antibody, transmembrane protein 88 antibody, transmembrane protein 88B antibody, transmembrane protein 88 a antibody, Tmem88 antibody, TMEM88 antibody, TMEM88B antibody, tmem88 antibody, tmem88a antibody
背景
Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.Synonyms: Transmembrane protein 88