This antibody detects CD244 / SLAMF4 at C-term. At least three isoforms of SLAMF4 are known to exist. The antibody is predicted to not cross-react with other SLAM protein family members.
交叉反应 (详细)
Species reactivity (tested):Human, mouse, rat
纯化方法
Affinity chromatography purified via peptide column
免疫原
16 amino acid peptide near the carboxy terminus of human SLAMF4
The signaling lymphocyte-activation molecule family member 4 (SLAMF4), also known as 2B4, is an important regulator of Natural Killer (NK) cell activation. It is expressed on NK cells as well as on subsets of T cells and interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in this autoimmune disease.Synonyms: NAIL, NK cell activation-inducing ligand, NK cell type I receptor protein 2B4, NKR2B4, Natural killer cell receptor 2B4