This antibody detects ZMIZ1 / RAI17 at N-term. At least three isoforms are known to exist, this antibody will recognize all three. ZIMP10 antibody is predicted to not cross-react with other PIAS protein family members.
交叉反应 (详细)
Species reactivity (tested):Human
纯化方法
Affinity chromatography purified via peptide column
免疫原
15 amino acid peptide near the amino terminus of human ZIMP10
ZIMP10, also known as ZMIZ1, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription)-like protein initially identified as a transcriptional co-activator of the androgen receptor (AR). ZIMP10 and the related protein ZIMP7 interact with PIAS3 and enhances AR-mediated transcription. Later experiments showed that ZIMP10 is also a co-activator of the p53 tumor suppressor. Mice deficient in ZIMP10 result in embryonic lethality by E10.5, these embryos reveal severe defects in the reorganization of the yolk sac vascular plexus, indicating that ZIMP10 plays an important role in proper vascular development.Synonyms: KIAA1224, PIAS-like protein Zimp10, Retinoic acid-induced protein 17, ZIMP10, Zinc finger MIZ domain-containing protein 1