This antibody detects DYRK1A at C-term. Multiple isoforms of DYRK1A are known to exist. DYRK1A antibody will not cross-react with other DYRK family members.
交叉反应 (详细)
Species reactivity (tested):Human, mouse, rat
纯化方法
Affinity chromatography purified via peptide column
免疫原
17 amino acid peptide near the carboxy terminus of human DYRK1A
DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2, this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.Synonyms: DYRK, Dual specificity YAK1-related kinase, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, HP86, MNB, MNBH, Protein kinase minibrain homolog