This antibody detects CTNNBL1 at C-term. CTNNBL1 antibody is predicted to not cross-react with other catenin family members. At least four isoforms of CTNNBL1 are known to exist, this antibody will detect all but isoform b.
交叉反应 (详细)
Species reactivity (tested):Human, mouse, rat
纯化方法
Affinity chromatography purified via peptide column
免疫原
20 amino acid peptide near the carboxy terminus of human CTTNBL1
ctnnbl1 antibody, MGC76112 antibody, MGC82423 antibody, PDGFRA antibody, MGC84931 antibody, C20orf33 antibody, NAP antibody, P14L antibody, PP8304 antibody, dJ633O20.1 antibody, 5730471K09Rik antibody, NYD-SP19 antibody, catenin beta like 1 antibody, catenin beta like 1 S homeolog antibody, catenin beta like 1 L homeolog antibody, catenin, beta like 1 antibody, ctnnbl1 antibody, CTNNBL1 antibody, ctnnbl1.S antibody, ctnnbl1.L antibody, Ctnnbl1 antibody
背景
The Beta-catenin-like protein 1 (CTNNBL1) contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs, as well as Armadillo/beta-catenin-like repeats. Transient expression of CTNNBL1 resulted in translocation to the nucleus and apoptosis, suggesting it may be involved in the apoptotic pathway. CTNNBL1 interacts with the Prp19 complex of the spliceosome and the Ig class switching enzyme activation-induced deaminase (AID) and had been suggested to play a role in antibody-diversification and class switching, but recent studies have shown CTNNBL1 to be dispensable for Ig class switch recombination. Other studies have identified CTTNBL1 as a novel gene for obesity.Synonyms: Beta-catenin-like protein 1, C20orf33, NYD-SP19, Nuclear-associated protein, Testis development protein NYD-SP19