This antibody detects ESRP2 / RBM35B at C-term. RBM35B antibody is predicted to not cross-react with other RBM35/ESRP family members. At least three isoforms of RBM35B are known to exist, this antibody will detect all three.
交叉反应 (详细)
Species reactivity (tested):Human, mouse
纯化方法
Affinity chromatography purified via peptide column
免疫原
17 amino acid peptide near the carboxy terminus of human RBM35B
RBM35A, also known as ESRP2, is a mRNA splicing factor that with its related protein RBM35A (ESRP1) are coordinators of an epithelial cell-type-specific splicing program. Both RBM35B and RBM35A are involved in posttranscriptional regulation of a number of genes such as FGFR2, CD44, CTNND1, and ENAH by exerting a differential effect on protein translation via 5' UTRs of mRNAs, suggesting that these proteins are global regulators of an epithelial regulatory network. Loss of this global ESRP-regulated epithelial splicing programme induces the phenotypic changes in cell morphology that are observed during the epithelial-mesenchymal transition.Synonyms: Epithelial splicing regulatory protein 2, RNA-binding motif protein 35B, RNA-binding protein 35B