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- 抗原 See all HMMR 抗体
- HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))
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抗原表位
- N-Term
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HMMR antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects CD168 / HMMR at N-term.
- 交叉反应 (详细)
- Species reactivity (tested):Human, mouse, rat
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- 18 amino acid peptide near the amino terminus of human RHAMM
- Top Product
- Discover our top product HMMR Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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Targeting Long Noncoding RNA HMMR-AS1 Suppresses and Radiosensitizes Glioblastoma." in: Neoplasia (New York, N.Y.), Vol. 20, Issue 5, pp. 456-466, (2018) (PubMed).
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Targeting Long Noncoding RNA HMMR-AS1 Suppresses and Radiosensitizes Glioblastoma." in: Neoplasia (New York, N.Y.), Vol. 20, Issue 5, pp. 456-466, (2018) (PubMed).
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- 抗原
- HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))
- 别名
- CD168 / HMMR (HMMR 产品)
- 别名
- AA386826 antibody, CD168 antibody, Rhamm antibody, RHAMM antibody, IHABP antibody, hyaluronan mediated motility receptor (RHAMM) antibody, hyaluronan-mediated motility receptor antibody, hyaluronan mediated motility receptor antibody, Hmmr antibody, HMMR antibody
- 背景
- The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.Synonyms: Hyaluronan mediated motility receptor, IHABP, Intracellular hyaluronic acid-binding protein, RHAMM, Receptor for hyaluronan-mediated motility
- 基因ID
- 3161
- NCBI登录号
- NP_001136028
- UniProt
- O75330
- 途径
- Glycosaminoglycan Metabolic Process
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