ASAH1 抗体 (AA 25-125)
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- 抗原 See all ASAH1 抗体
- ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
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抗原表位
- AA 25-125
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ASAH1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- Recognizes Acid ceramidase ASAH1.
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Protein A Chromatography
- 免疫原
- ASAH1 antibody was raised against ASAH1 (NP_808592, 25 a.a. ~ 125 a.a) partial recombinant protein with GST tag.
- 克隆位点
- 1A7
- 亚型
- IgG3
- Top Product
- Discover our top product ASAH1 Primary Antibody
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anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 144-395) antibody
ASAH1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 25-124) antibodyASAH1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 146-395) antibodyASAH1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 25-125) antibodyASAH1 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 22-395) antibodyASAH1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 146-395) antibodyASAH1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 1-395) antibodyASAH1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (N-Term) antibodyASAH1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Bat, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (AA 140-389) antibodyASAH1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) (N-Term) antibodyASAH1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, pH 7.2
- 注意事项
- Avoid freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Store the antibody (in aliquots) at -20° or -80 °C.
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- 抗原
- ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
- 别名
- Acid Ceramidase (ASAH1 产品)
- 别名
- AC antibody, ACDase antibody, ASAH antibody, PHP antibody, PHP32 antibody, SMAPME antibody, 2310081N20Rik antibody, Asah antibody, MGC82286 antibody, asah1 antibody, zgc:101637 antibody, ASAH1 antibody, zgc:66026 antibody, N-acylsphingosine amidohydrolase 1 antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1 antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1 L homeolog antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1a antibody, Acid ceramidase antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1b antibody, ASAH1 antibody, Asah1 antibody, asah1.L antibody, asah1a antibody, asah-1 antibody, asah1b antibody
- 背景
- Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer's disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. Multiple isoforms of this protein are known to exist.Synonyms: ASAH, ASAH1, Acylsphingosine deacylase, N-acylsphingosine amidohydrolase, PHP32, Putative 32 kDa heart protein
- 基因ID
- 427
- NCBI登录号
- NP_001120977
- UniProt
- Q13510
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