This Monoclonal antibody detects Human/Porcine Trefoil Factor 1 (TFF1). Antigen Distribution: The antigen has been described in stomach, with highest levels in the upper gastric mucosal cells. Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the. Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system. Detected in urine. Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (Swissprot).
交叉反应 (详细)
Species reactivity (tested):Human, Pig.
纯化方法
Affinity Chromatography
免疫原
Peptide C57 to F84 from Human Trefoil Factor 1. Antigen/Epitope: The antigen is Trefoil Factor 1, the epitope is located in the C-terminal region.
Trefoil Factor 1 has been described as a stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. TFF1 may inhibit the growth of calcium oxalate crystals in urine.Synonyms: BCEI, Breast cancer estrogen-inducible protein, PNR-2, Polypeptide P1.A, TFF1