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Complement C3c 抗体

C3C 适用: 人 ELISA, IHC, IHC (fro), IHC (p) 宿主: 绵羊 Polyclonal unconjugated
产品编号 ABIN768895
发货至: 中国
  • 抗原 See all Complement C3c (C3C) products
    Complement C3c (C3C) (Complement Component C3c (C3C))
    适用
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    宿主
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    绵羊
    克隆类型
    • 114
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    多克隆
    标记
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    This Complement C3c antibody is un-conjugated
    应用范围
    • 70
    • 50
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    ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    品牌
    IHC-plus™
    特异性
    Detects human complement 3c, a polypeptide fragment which is present in C3. C3 plays a central role in the activation of the complement system. Processing of C3 by C3 convertase is the central reaction in both classical and alternative complement pathways, resulting in C3a and C3b. C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates, and help to initiate the complement cascade, potentially resulting in cellular apoptosis. C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c and C3dg. Defects in C3 can result in susceptibility to pyogenic infection. Shows minimal reactivity with related serum proteins.
    纯化方法
    Protein G purified
    免疫原
    Native human C3 / Complement C3.
    亚型
    IgG
  • 应用备注
    Approved: ELISA (1:400), IHC, IHC-Fr (1:50), IHC-P (5 μg/mL)
    说明

    Target Species of Antibody: Human

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    PBS, 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    avoid freeze thaw cycles.
    储存条件
    4 °C,-20 °C
    储存方法
    Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
  • 抗原
    Complement C3c (C3C) (Complement Component C3c (C3C))
    别名
    Complement C3/C3c (C3C 产品)
    UniProt
    P01024
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