SIRT7 抗体 (AA 231-330)
(2 references)-
- 抗原 See all SIRT7 抗体
- SIRT7 (Sirtuin 7 (SIRT7))
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抗原表位
- AA 231-330
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SIRT7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 小鼠
- 预测反应
- Human,Rat,Dog,Pig,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human SIRT7
- 亚型
- IgG
- Top Product
- Discover our top product SIRT7 Primary Antibody
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anti-Sirtuin 7 (SIRT7) (AA 1-400) antibody
SIRT7 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) antibodySIRT7 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 1-400) antibodySIRT7 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 201-400) antibodySIRT7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 1-105) antibodySIRT7 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1E2B2 unconjugated
anti-Sirtuin 7 (SIRT7) (AA 242-379) antibodySIRT7 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 317-366) antibodySIRT7 适用: 人, 大鼠, 小鼠, 犬, Cow, 马, Pig, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 35-51), (AA 361-377) antibodySIRT7 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 8-350) antibodySIRT7 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 7 (SIRT7) (AA 1-400) antibodySIRT7 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- SIRT7 (Sirtuin 7 (SIRT7))
- 别名
- Sirt7 (SIRT7 产品)
- 别名
- SIRT7 antibody, LOC796135 antibody, SIR2L7 antibody, sirtuin 7 antibody, phosphate cytidylyltransferase 2, ethanolamine antibody, SIRT7 antibody, sirt7 antibody, PCYT2 antibody, Sirt7 antibody
- 背景
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Synonyms: SIR2L7, NAD-dependent protein deacetylase sirtuin-7, Regulatory protein SIR2 homolog 7, SIR2-like protein 7, SIRT7
Background: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
- 基因ID
- 51547
- UniProt
- Q9NRC8
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