AF4 抗体 (AA 31-130) (Biotin)
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- 抗原 See all AF4 (AFF1) products
- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
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抗原表位
- AA 31-130
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AF4 antibody is conjugated to Biotin
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应用范围
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human AF 4 protein
- 亚型
- IgG
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anti-AF4/FMR2 Family, Member 1 (AFF1) (AA 1181-1210) antibody
AFF1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-AF4/FMR2 Family, Member 1 (AFF1) (N-Term) antibodyAFF1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-AF4/FMR2 Family, Member 1 (AFF1) antibodyAFF1 适用: 人, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-AF4/FMR2 Family, Member 1 (AFF1) (AA 1-183) antibodyAFF1 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
- 别名
- AF4 (AFF1 产品)
- 别名
- AF4 antibody, MLLT2 antibody, PBM1 antibody, 9630032B01Rik antibody, AW319193 antibody, Af4 antibody, Mllt2h antibody, Rob antibody, Mllt2 antibody, AF4/FMR2 family member 1 antibody, AF4/FMR2 family, member 1 antibody, AFF1 antibody, Aff1 antibody
- 背景
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Synonyms: AF 4, AF 4 protein, AF-4 protein, AF4/FMR2 family member 1, AFF 1, AFF1, AFF1_HUMAN, ALL1 fused gene from chromosome 4, ALL1-fused gene from chromosome 4 protein, FEL, MLLT2, MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2, MLLT2, Protein AF-4, Protein FEL, Proto-oncogene AF4.
Background: Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.
- 基因ID
- 4299
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