RPH3AL 抗体 (AA 25-130) (Biotin)
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- 抗原 See all RPH3AL 抗体
- RPH3AL (Rabphilin 3A-Like (Without C2 Domains) (RPH3AL))
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抗原表位
- AA 25-130
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RPH3AL antibody is conjugated to Biotin
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 小鼠
- 预测反应
- Human,Rat,Dog,Cow,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human RPH3AL
- 亚型
- IgG
- Top Product
- Discover our top product RPH3AL Primary Antibody
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anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 161-315) antibody
RPH3AL 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 161-315) antibodyRPH3AL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 1-315) antibodyRPH3AL 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 208-237), (C-Term) antibodyRPH3AL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB24121 unconjugated
anti-Rabphilin 3A-Like (Without C2 Domains) (RPH3AL) (AA 211-241), (C-Term) antibodyRPH3AL 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- RPH3AL (Rabphilin 3A-Like (Without C2 Domains) (RPH3AL))
- 别名
- RPH3AL (RPH3AL 产品)
- 别名
- NOC2 antibody, 6530413F01Rik antibody, AI551877 antibody, Gm1753 antibody, Noc2 antibody, rabphilin 3A like (without C2 domains) antibody, rabphilin 3A-like (without C2 domains) antibody, RPH3AL antibody, Rph3al antibody
- 背景
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Synonyms: Noc2, Rab effector Noc2, Rabphilin 3A-like without C2 domains, Rabphilin 3A-like, Rabphilin-3A-like protein, RPH3AL, RPH3L_HUMAN, No C2 domains protein, Gm1753.
Background: Rabphilin-3AL (rabphilin-3A-like), also known as RPH3AL or NOC2, is a cytoplasmic Rab GTPase effector. It contains one FYVE-type zinc finger and one Rab-binding (RBD) domain, but unlike its related protein, rabphilin-3A, rabphilin-3AL does not contain any C2 domains. Rabphilin-3AL is expressed in a variety of tissues, with highest levels found in kidney, skeletal muscle, pancreas, liver, ovary, stomach, heart and thyroid. It is believed to play a role regulating calcium-dependent secretory vesicle exocytosis in endocrine and exocrine cells. Via its RBD domain, rabphilin-3AL is capable of binding Rab 27a and, through this interaction, rabphilin-3AL is recruited to dense-core vesicles. With lower affinity, rabphilin-3AL can also bind Rab 3 and Rab 8 with its RBD domain. Through an interaction with Rab 3, rabphilin-3AL can inhibit G-protein signaling in endocrine pancreas and positively regulate insulin secretion. Rabphilin-3AL knockout mice display accumulation of secretory granules and irregular shape in exocrine cells.
- 基因ID
- 9501
- 途径
- Carbohydrate Homeostasis, Regulation of G-Protein Coupled Receptor Protein Signaling
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