SLIT2 抗体 (AA 451-550)
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- 抗原 See all SLIT2 抗体
- SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))
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抗原表位
- AA 451-550
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SLIT2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 大鼠
- 预测反应
- Human,Mouse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Slit2
- 亚型
- IgG
- Top Product
- Discover our top product SLIT2 Primary Antibody
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))
- 别名
- SLIT2/Slil3 (SLIT2 产品)
- 别名
- SLIL3 antibody, Slit-2 antibody, Drad-1 antibody, E030015M03Rik antibody, E130320P19Rik antibody, Slil3 antibody, mKIAA4141 antibody, Slit antibody, slil3 antibody, slit-2 antibody, slit2-a antibody, SLIT2 antibody, slit guidance ligand 2 antibody, slit homolog 2 (Drosophila) antibody, slit guidance ligand 2 S homeolog antibody, SLIT2 antibody, Slit2 antibody, slit2 antibody, slit2.S antibody
- 背景
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Synonyms: SLIL3, Slit-2, Slit homolog 2 protein, SLIT2
Background: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
- 基因ID
- 9353
- UniProt
- O94813
- 途径
- Regulation of Actin Filament Polymerization, Regulation of Cell Size, Smooth Muscle Cell Migration
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