DDB2 抗体 (AA 201-300)
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- 抗原 See all DDB2 抗体
- DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
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抗原表位
- AA 201-300
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适用
- 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DDB2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- This antibody may have a minor secondary cross-reactivity to TNFAIP3-interacting protein 2 due to a 63 % non-sequential sequence similarity in the immunogen region.
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Human,Cow,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human DDB2
- 亚型
- IgG
- Top Product
- Discover our top product DDB2 Primary Antibody
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anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 1-315) antibody
DDB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) antibodyDDB2 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 166-383) antibodyDDB2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 1-427) antibodyDDB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) antibodyDDB2 适用: 人 WB, ICC, DB 宿主: 小鼠 Monoclonal 2246C4a unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) antibodyDDB2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 1-185) antibodyDDB2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (AA 1-109) antibodyDDB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F11 unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (C-Term) antibodyDDB2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (C-Term) antibodyDDB2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
- 别名
- DDB2 (DDB2 产品)
- 别名
- 2610043A19Rik antibody, si:dkey-45f10.3 antibody, DDBB antibody, UV-DDB2 antibody, damage specific DNA binding protein 2 antibody, damage-specific DNA binding protein 2 antibody, DDB2 antibody, ddb2 antibody, Ddb2 antibody
- 背景
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Synonyms: DDBB, UV-DDB2, DNA damage-binding protein 2, DDB p48 subunit, Damage-specific DNA-binding protein 2, UV-damaged DNA-binding protein 2, UV-DDB 2, DDB2
Background: Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.
- 基因ID
- 1643
- UniProt
- Q92466
- 途径
- DNA Damage Repair
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