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MST1 抗体 (AA 385-487)

Name: MST1 抗体 (AA 385-487)
SKU: ABIN747308
Availability: OutOfStock

MST1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Mouse liver lysates probed with Rabbit Anti-MST1 Polyclonal Antibody, Unconjugated at 1:500 for 90 min at 37˚C. (MST1 抗体 (AA 385-487))

Mouse liver lysates probed with Rabbit Anti-MST1 Polyclonal Antibody, Unconjugated at 1:5000 for 90 min at 37˚C. (MST1 抗体 (AA 385-487))

Formalin-fixed and paraffin embedded human prostate labeled with Anti-MST1 Polyclonal Antibody, Unconjugated at 1:300 followed by conjugation to the secondary antibody and DAB staining. (MST1 抗体 (AA 385-487))

IHC (p)

Formalin-fixed and paraffin embedded human laryngeal labeled with Anti-MST1 Polyclonal Antibody, Unconjugated at 1:300 followed by conjugation to the secondary antibody and DAB staining. (MST1 抗体 (AA 385-487))

7 images

产品编号 ABIN747308

发货至: 中国

Datasheet as PDF

抗原 See all MST1 抗体

MST1 (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1))
抗原表位
15

8

7

6

5

4

3

2

2

2

1

1

1

1

1

1
AA 385-487
适用
55

25

19

3

2

2

2

2

1
人, 小鼠, 大鼠
宿主
51

7
兔
Compatible Secondaries
克隆类型
53

5
多克隆
标记
26

5

4

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MST1 antibody is un-conjugated
应用范围
43

24

20

18

12

12

7

4

3

3

2

2

1
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人, 小鼠, 大鼠

预测反应

Dog,Cow,Horse,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human MST1

亚型

IgG
anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 200-500) antibody
MST1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) antibody
MST1 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated

anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 454-483) antibody
MST1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 489-716) antibody
MST1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (C-Term) antibody
MST1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 385-415), (C-Term) antibody
MST1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB1193 unconjugated

anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 363-465) antibody
MST1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 1-711) antibody
MST1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 540-589) antibody
MST1 适用: 人, 犬, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 469-704) antibody
MST1 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

MST1 (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1))

别名

MST1 (MST1 产品)

背景

Synonyms: KRS2, MST1, YSK3, TIIAC, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, MST-1, STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2, STK4
Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

基因ID

6789

UniProt

Q13043